Biological applications of ionophores

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WebMar 1, 2024 · Herein, the biological applications of Zn ionophores are reviewed, discussing the coordination chemistry, the mechanism of action, and interactions with target … WebBiological applications and evolutionary origins of ionophores. Pressman BC , deGuzman NT Adv Exp Med Biol, 84:285-300, 01 Jan 1977 Cited by: 6 articles PMID: …

Zinc ionophores: chemistry and biological applications

WebAug 13, 2024 · Labile zinc, a tiny fraction of total intracellular zinc that is loosely bound to proteins and easily interchangeable, modulates the activity of numerous signaling and … WebMay 30, 2013 · Moreover, the discovery of salinomycin and other natural ionophores as CSC-selective drugs opened up the possibility of repurposing these drugs for novel applications in human medicine ... porth mawr caernarfon

Biological applications of ionophores. Sigma-Aldrich

WebJul 1, 1976 · Ionophores are compounds of moderate molecular weight (about 200-2(00) that form lipid-soluble complexes with polar cations, of which K+, Na+, Ca2+, Mg2+, and … WebFeb 15, 2015 · 6 Structure and Biological Activity of Polyether Ionophores and Their. ... Practical applications The present study is the first to study the effect of M. longifolia in an experimental model of ... WebMay 27, 2024 · Despite several ionophores revealing potential therapeutic applications as apoptosis inducers, ... In the context of transporting molecules of biological relevance, quite a few ionophores have been … porth meaning

Calcium Chelators and Calcium Ionophores SpringerLink

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WebIonophores transport ions across biological membranes and have wide-ranging applications, but a platform for their rapid development does not exist. We report a platform for developing ionophores from metal-ion chelators, which are readily available with wide-ranging affinities and specificities, and structural data that can aid rational design. WebMar 15, 2024 · As such, an essential part of all applications is a letter of sponsorship from the BSD faculty member with whom the applicant proposes to work, outlining the … porth mear coveWebThe Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous … porth menshed

"WebPolyether ionophores are complex natural products capable of transporting cations across biological membranes. Many polyether ionophores possess potent antimicrobial activity and a few selected compounds have the ability to target aggressive cancer cells. Nevertheless, ionophore function is believed … " - Biological applications of ionophores

Biological applications of ionophores

WebThe structure and physical chemical properties are reviewed of various ionophores, small molecules which transport cations across biological membranes. The subclass of carboxylic ionophores has dramatic pharmacological properties, dilating the coronary arteries and increasing cardiac contractility, which make them especially interesting. WebJan 1, 2024 · Biological Applications of Ionophores. Article. Feb 1976; Berton C. Pressman; View. Effects of a low protein diet during pregnancy of the rhesus monkey. I. Reproductive efficiency. Article.

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WebBiological applications of ionophores. Pressman BC. Annual Review of Biochemistry , 01 Jan 1976, 45: 501-530 DOI: 10.1146 ... Biological applications and evolutionary origins of ionophores. Pressman BC, deGuzman NT. Adv Exp Med Biol, 84:285-300, 01 Jan 1977 WebJan 15, 2000 · Monopodal and oligopodal Mg2+-selective ionophores were characterized by their selectivity coefficients (Separate Solution Method, SSM) in plasticized poly ... “Chemical Sensors and Biosensors for Medical and Biological Applications”, 1998, Wiley–VCH, Weinheim. M. Müller, M. Rouilly, B. Rusterholz, M. Maj-Zurawska, Z. Hu, …

WebPressman BC (1976) Biological applications of ionophores. Ann Rev Biochem 45:501–530. CrossRef PubMed CAS Google Scholar Puskin JS, Gunter TE (1975) Electron paramagnetic resonance of copper ion and manganese ion complexes with the ionophore A23187. Biochemistry 14:187–191 . CrossRef ... WebMar 4, 2024 · The development of new therapeutic agents should aim to increase selectivity and therefore reduce side effects. In addition, these agents should overcome cancer cell resistance and target cancer ...

WebOct 9, 2016 · Biological applications of ionophores. Annu Rev Biochem. 1976; 45:501–530. [Google Scholar] Reiner R, Weiss U, Brombacher U, Lanz P, Montavon M, Furlenmeier A, Angehrn P, Probst PJ. Ro 13-9904/001, a novel potent and long-acting parenteral cephalosporin. J ... WebDec 21, 2024 · Zinc ionophores increase the intracellular concentration of Zinc ions causing significant biological effects. This review provides, for the first time, an overview of the …

WebThe control of ion transport and homeostasis is a critical function of living organisms. In this perspective, an overview of different synthetic systems capable of facilitating the transmembrane transport of ions along with the biological activity exerted by these compounds is presented. Examples of both cat

WebNatural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to … porth meaning cornwallIn chemistry, an ionophore (from Greek ion and -phore 'ion carrier') is a chemical species that reversibly binds ions. Many ionophores are lipid-soluble entities that transport ions across the cell membrane. Ionophores catalyze ion transport across hydrophobic membranes, such as liquid polymeric membranes (carrier-based ion selective electrodes) or lipid bilayers found in the living cells or synthetic vesicles (liposomes). Structurally, an ionophore contains a hydrophilic center … porth mellin coatWebAs it has turned out, medical and pharmaceutical applications of ionophores are limited, since the activity of ionophores is not restricted to microbial membranes. On the other hand, ionophores were found to be wonderful tools in biochemical research at the cellular or membrane level. ... Pressman, B.C.: Biological applications of ionophores ... porth medical centreWebAs it has turned out, medical and pharmaceutical applications of ionophores are limited, since the activity of ionophores is not restricted to microbial membranes. On the other … porth mellinWebBiological applications of ionophores. by B C Pressman. Annual review of biochemistry. Read more related scholarly scientific articles and abstracts. porth mens shedWebApr 13, 2024 · Matthew Songer, (Biological Sciences ’79) and Laura Songer (Biological Sciences ’80) have generously donated funds to the College of Sciences and Arts (CSA) … porth meudwy coastal walkWebFeb 12, 2024 · Ion-selective electrodes (ISEs) are one of the most established types of chemical sensors, commercialized for a wide variety of applications ranging from their use as indicator electrodes in titrations to the direct determination of ions in clinical analysis. 1 This latter application has been largely aided by the implementation of ionophore-based … porth mellin waterproof coat