Cancer therapeutic resistance
WebOvercoming intrinsic and acquired resistance of cancer stem/progenitor cells to current clinical treatments represents a major challenge in treating and curing the most aggressive and metastatic cancers. This review summarizes recent advances in our understanding of the cellular origin and molecular mechanisms at the basis of cancer initiation ... WebApr 14, 2024 · Sphingosine kinase 1 is a protooncogene associated with therapeutic resistance in breast cancer [164,165] and can be inhibited with the synthetic structural analog of sphingosine, Fingolimod (FTY720) [166,167]. Interestingly, FTY720 inhibits autophagy and triggers apoptosis in trastuzumab-resistant breast cancer cells .
Cancer therapeutic resistance
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WebNov 3, 2024 · Concerning their role in resistance to molecular therapies, Sansone and colleagues demonstrated that CAFs can sustain hormonal therapy resistance in luminal breast cancer through the release of miR-221 containing exosomes; the horizontal transfer of this microRNA to cancer cells pushed them towards a cancer stem cell (CSC) … WebProstate cancer is the second leading cause of cancer deaths in the USA. The challenge in managing castration-resistant prostate cancer (CRPC) stems not from the lack of therapeutic options but from the limited duration of clinical and survival benefit offered by treatments in this setting due to primary and acquired resistance.
WebMar 1, 2024 · Understanding, predicting, and circumventing resistance to targeted cancer therapy is now a major endeavor for translational cancer biologists to undertake. … WebAug 9, 2024 · Resistance to targeted therapies is a major challenge in cancer care and occurs via genetic and non-genetic mechanisms. In this issue of Cancer Cell, Marin …
WebTherapeutic resistance is a process which is unpredictable and difficult to model. Therefore, better tools are needed to identify or predict resistance mechanisms. This … WebThe view of cancer as a tumor cell-centric disease is now replaced by our understanding of the interconnection and dependency of tumor stroma. Cancer-associated fibroblasts …
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WebOct 9, 2024 · This paper reviews the possible mechanisms of NF1 mutation-induced therapeutic resistance to chemotherapy, endocrine therapy and targeted therapy in malignancies. Then, we further discuss advancements in targeted therapy for NF1-mutated malignant tumors. ... Inhibition of tumor angiogenesis as a strategy to circumvent … how to spell forty dollarsWebAbstract. Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy. In the clinic, therapeutic resistance is largely attributed to tumor heterogeneity. Growing … rdp investmentsWebMultiple Drug Resistance (MDR) Failure of the drugs to enter the target cell and/or drug ejection: There are several reasons why drugs may not reach therapeutic levels within … rdp keyboard layoutWebA new clinical and preclinical study from UCLA Jonsson Comprehensive Cancer Center identifies the DNA roots of resistance to targeted cancer therapy, providing a possible strategy to address a vexing issue in cancer therapeutics. Results are published online ahead of print in Cancer Discovery, a journal of the American Association for Cancer … rdp keep alive windows 10WebApr 13, 2024 · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using … rdp into windows 11 with microsoft accountWebAcquired resistance to ALK TKIs inevitably occurs in patients who initially respond to therapy. Gainor et al showed that resistance mutations are common in second … how to spell forty fiveWeb2 days ago · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using … rdp instance