T-2 toxin is hydroxylated by chicken cyp3a37
WebMetabolism of T-2 Toxin in Farm Animals and Human In Vitro and in Chickens In Vivo Using Ultra High-Performance Liquid Chromatography- Quadrupole/Time-of-Flight Hybrid Mass … WebMay 5, 2024 · On the basis of characterized functional groups, trichothecenes can be classified into four groups. Type A trichothecenes are mainly represented by T-2 toxins …
T-2 toxin is hydroxylated by chicken cyp3a37
Did you know?
WebSep 10, 2024 · T-2 toxin is the most toxic trichothecene mycotoxin, and it exerts potent toxic effects, including immunotoxicity, neurotoxicity, and reproductive toxicity. Recently, several novel metabolites, including 3′,4′-dihydroxy-T-2 toxin … WebAug 15, 1988 · T-2 toxin is hydroxylated by chicken CYP3A37 2013, Food and Chemical Toxicology Citation Excerpt : Hydrolysis, glucuronide conjugation, deepoxidation and hydroxylation are major metabolic reactions in the pathway of T-2 biotransformation (He et al., 2010; Kuca et al., 2008; Li et al., 2011).
WebSearch life-sciences literature (39,398,388 articles, preprints and more) Search. Quick link: Coronavirus articles and preprints WebSep 30, 2013 · Our results showed that chicken CYP3A37 is able to convert T-2 to 3'-OH T-2 with an apparent Km of 15.29 μM, and T-2 hydroxylation activity of CYP3A37 is strongly …
WebMay 23, 2013 · T-2 toxin is a naturally occurring contaminant of agricultural commodities. It has been shown that the average T-2 toxin contamination in chicken feed ranges between 0.03 and 0.155 mg/kg [ 23 – 26 ]. The concentration of T-2 toxin used (0.1 μg/mL) in this study is just located at this range. 3.2. WebApr 10, 2013 · The transmission of T-2 toxin and its metabolites into the edible tissues of poultry has potential effects on human health. We report that T-2 toxin significantly induces CYP1A4 and CYP1A5 expression in chicken embryonic hepatocyte cells. The enzyme activity assays of CYP1A4 and CYP1A5 heterologously expressed in HeLa cells indicate …
WebPreliminary metabolic studies of carp reveal that ester hydrolysis of T-2 toxin in carp may not play as important a role as is the case with land animals. 45 Highly Influenced View 1 …
WebT-2 toxin is hydroxylated by chicken CYP3A37. scientific article published on 30 September 2013. Statements. instance of. scholarly article. 1 reference. stated in. Europe PubMed Central. PubMed ID. 24090734. retrieved. howl\u0027s moving castle for violinhowl\u0027s moving castle full movie downloadWebSep 30, 2013 · Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer" Smith J high waisted pants plus size tightWebDec 1, 2014 · The excellent detection sensitivity in various matrices of T-2 toxin (T-2), which has cytotoxic and immunosuppressive effects in DNA and RNA synthesis, is a highly desirable characteristic. A... howl\u0027s moving castle full movie animeWebT-2 toxin (T-2) is an acute toxic trichothecene mycotoxin produced mainly by Fusarium species, detected in many crops including oats, wheat and barley, in animal feed and food. … high waisted pants mustard with a bowWebJul 2, 2015 · CYP3A37 converted T-2 toxin to 3′-OH T-2, and the T-2 hydroxylation activity of CYP3A37 was strongly inhibited by ketoconazole. Chicken CYP3A37 can also catalyze erythromycin N-demethylation, which is another CYP3A-specific activity. high waisted pants mens keeping them upWebAlthough T-2 toxin occurs naturally in cereal grains, contamination with T-2 toxin is less frequent than with deoxynivalenol (DON). However, T-2 toxin (LD50 in mice: 2–4 mg kg … high waisted pants mustard with a bow skinny