WebThe puzzling role of TRPC3 channels in motor coordination. Mohamed Trebak. Department of Cellular and Molecular Physiology; Penn State Cancer Institute; Cancer Institute, … WebAug 14, 2008 · Importantly, TRPC3 knockout mice exhibit an impaired walking behavior. Taken together, our results establish TRPC3 as a new type of postsynaptic channel that mediates mGluR-dependent synaptic transmission in cerebellar Purkinje cells and is crucial for motor coordination.

TRPC3 channel mediates excitation of striatal cholinergic

WebOct 14, 2009 · These reports described apparently similar motor coordination defects in TRPC3 knockout mice and in mice with a TRPC3 gain-of-function mutation, and thus … WebFeb 16, 2011 · The hereditary cerebellar ataxias are a diverse group of neurodegenerative disorders primarily characterised by loss of balance and coordination due to dysfunction of the cerebellum and its associated pathways. Although many genetic mutations causing inherited cerebellar ataxia have been identified, a significant percentage of patients … no find function

TRPC3 - an overview ScienceDirect Topics

WebAug 14, 2008 · TRPC3 is the most abundantly expressed TRPC subunit in Purkinje cells. In mutant mice lacking TRPC3, both slow synaptic potentials and mGluR-mediated inward … WebJun 5, 2015 · Consequences of altered Trpc3 expression in mouse models. The cerebellum plays an important role in the fine-tuning, coordination, and accurate timing of movements as well as in motor learning . In mice with an altered expression of TRPC3 characteristic, clear motoric deficits were observed. WebTRPC3 is mainly expressed in the brain and various other tissues, though at a much lower level (2). In the brain, TRPC3 is involved in BDNF-induced axonal growth cone plasticity, dendritic spine formation, and neuronal survival (3-6). It is also required for synaptic transmission and motor coordination (7). nus create account